24 Chromosome Microarray
About PGD by 24 Chromosome Microarray (aCGH)
Chromosome abnormalities (aneuploidies) are associated with failed implantation, pregnancy loss, and the birth of children with multiple congenital anomalies. Preimplantation genetic diagnosis (PGD) provides a means of testing for these chromosome abnormalities and selecting the best embryos for transfer. Embryos with chromosome abnormalities are almost always physically indistinguishable from healthy embryos; therefore, without PGD, abnormal embryos are equally likely to be transferred, reducing the chances of achieving a viable and healthy pregnancy.
Prior aneuploidy testing involved analysis of a single cell by fluorescence in situ hybridization (FISH), using probes for a limited number of chromosomes. FISH testing is able to detect the most common chromosome abnormalities, including Down syndrome, Trisomy 18, Trisomy 13, and sex chromosome anomalies, in order to reduce the risk of having an affected pregnancy or child.
Research shows, however, that abnormalities involving any chromosome can increase the risk of miscarriage and reduce the effectiveness of IVF. RGI’s 24-chromosome testing is able to analyze the entire chromosome complement of a single cell, reducing the risk of failed implantation and miscarriage, and increasing the chance of having a healthy baby.
RGI performs 24-chromsome analysis using a technique called microarray, or array comparative genome hybridization (aCGH). This technique compares the amount of DNA present for each chromosome in a single cell, and compares it to that of a normal standard. Microarray can be performed on three different sample types: polar bodies (from fertilized eggs), blastomeres (from Day 3 embryos), or blastocyst/trophectoderm (from Day 5/6 embryos). Embryo transfer during the same cycle is feasible for polar body and/or blastomere testing, whereas trophectoderm testing typically requires embryo freezing and thawing for transfer at a later date. Results are concise and reliable, and our genetic counselors are available to provide clear interpretation of the data.
RGI’s 24-chromosome testing does not require submission of blood or saliva samples, and there is no waiting period or penalty for cancellations.
Please contact one of our genetic counselors via email or at 773-472-4900 for more information about 24-chromosome testing or to set up a free consultation.